HH-5 工业丙二酸二甲酯测定毛细管柱

名称：毛细管柱

固定相：5%苯基-95%二甲基聚硅氧烷

规格：30m*0.32mm*0.5um

型号：HH-5

丙二酸二甲酯(DMM)是一种重要的医药中间体,广泛应用于各类有机合成反应。目前工业上通用的DMM生产方法主要有氰化法和羰基化法两大类,但这两类方法都存在各自难以克服的问题：氰化法收率较低,且生产中使用剧毒的氰化钠,易造成环境污染和人身伤害；羰基化法生产过程需要用到铑、钯等贵金属催化剂,增加了成本,且反应条件较苛刻,危险性较大。

浩瀚色谱（山东）应用技术开发有限公司，研发气相色谱法测定工业丙二酸二甲酯，HH-5毛细管柱测定，面积归一法定量，结果满意。

工业丙二酸二甲酯测定毛细管柱  测试谱图：



Determination of dimethyl malonate for industrial use Capillary column

Details of capillary column for determination of dimethyl malonate for industrial use:



Name: capillary column



Stationary phase: 5% phenyl-95% dimethyl polysiloxane



Specification: 30m * 0.32mm * 0.5um



Model: HH-5



Dimethyl malonate (DMM) is an important pharmaceutical intermediate, which is widely used in various organic synthesis reactions. At present, DMM production methods commonly used in industry mainly include cyanidation method and carbonylation method, but these two methods have their own problems that are difficult to overcome: cyanidation method has low yield, and the use of highly toxic sodium cyanide in production is easy to cause environmental pollution and personal injury; The carbonylation process requires the use of noble metal catalysts such as rhodium and palladium, which increases the cost, and the reaction conditions are harsh and dangerous.



Haohan Chromatography (Shandong) Application Technology Development Co., Ltd. has developed a gas chromatography method for the determination of industrial dimethyl malonate, a HH-5 capillary column method for the determination, and an area normalization method for the quantification. The results are satisfactory.



Capillary column test spectrogram for determination of industrial dimethyl malonate: